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Parcourir par sujet "gene therapy"

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    • Efficient liver gene transfer with foamy virus vectors 

      Zacharoulis, D.; Rountas, C.; Katsimpoulas, M.; Morianos, J.; Chatziandreou, I.; Vassilopoulos, G. (2013)
      Liver gene transfer offers hope for the correction of genetic and acquired disorders. Efficient gene transfer in large animals can be obtained with hydrodynamic gene transfer (HGT), a method that can achieve sufficient ...

    • FV vectors as alternative gene vehicles for gene transfer in HSCs 

      Simantirakis E., Tsironis I., Vassilopoulos G. (2020)
      Hematopoietic Stem Cells (HSCs) are a unique population of cells, capable of reconstituting the blood system of an organism through orchestrated self-renewal and differentiation. They play a pivotal role in stem cell ...

    • International consensus on the diagnosis and management of pediatric patients with hereditary angioedema with C1 inhibitor deficiency 

      Farkas H., Martinez-Saguer I., Bork K., Bowen T., Craig T., Frank M., Germenis A.E., Grumach A.S., Luczay A., Varga L., Zanichelli A., HAWK, Aberer W., Andrejevic S., Aygoeren-Pürsün E., Banerji A., Bara N.-A., Bas M., Bernstein J., Betschel S., Björkander J., Boccon-Gibod I., Bouillet L., Bova M., Boysen H.H., Branco-Ferreira M., Bygum A., Caballero T., Cancian M., Castaldo A., Christiansen S., Cicardi M., Drouet C., Fabiani J., Gompels M., Gonzalez-Quevedo M.T., Gooi J., Gower R., Gökmen N.M., Grivcheva-Panovska V., Guilarte M., Gülbahar O., Hack E., Hakl R., Harmat G., Jeseňák M., Jolles S., Kaplan A., Katelaris C., Kosnik M., Kőhalmi K.V., Leibovich I., Levi M., Li H., Longhurst H.J., Lumry W., Magerl M., Malbran A., Martin L., Maurer M., Mihály E., Moldovan D., Murdjeva M., Nagy I.B., Nielsen E.W., Nieto S., Nordenfelt P., Obtulowitzc K., Pedrosa M., Porębski G., Prior N., Reshef A., Riedl M.A., Rosenkranz B., Schmid-Grendelmeier P., Péter S., Speletas M., Staevska M., Stobiecki M., Triggiani M., Veszeli N., Wuillemin W., Xiang Z.Y., Yamamoto B., Zuraw B. (2017)
      Background: The consensus documents published to date on hereditary angioedema with C1 inhibitor deficiency (C1-INH-HAE) have focused on adult patients. Many of the previous recommendations have not been adapted to pediatric ...

    • Minimally invasive and selective hydrodynamic gene therapy of liver segments in the pig and human 

      Khorsandi, S. E.; Bachellier, P.; Weber, J. C.; Greget, M.; Jaeck, D.; Zacharoulis, D.; Rountas, C.; Helmy, S.; Helmy, A.; Al-Waracky, M.; Salama, H.; Jiao, L.; Nicholls, J.; Davies, A. J.; Levicar, N.; Jensen, S.; Habib, N. (2008)
      This paper highlights our experience of the transfer of hydrodynamic gene therapy (HGT) from the large animal, the pig, into clinical practice. The modification of balloon catheters and the development of a minimally ...

    • Non-coding RNAs in cancer-associated cachexia: clinical implications and future perspectives 

      Kottorou A., Dimitrakopoulos F.-I., Tsezou A. (2021)
      Cachexia is a multifactorial syndrome characterized by skeletal muscle loss, with or without adipose atrophy, irreversible through nutritional support, in the context of systemic inflammation and metabolic disorders. It ...

    • RNA-Mediated therapeutics: From gene inactivation to clinical application 

      Kalavrizioti, D.; Vourekas, A.; Stamatopoulou, V.; Toumpeki, C.; Giannouli, S.; Stathopoulos, C.; Drainas, D. (2006)
      The specific targeting and inactivation of gene expression represents nowdays the goal of the mainstream basic and applied biomedical research. Both researchers and pharmaceutical companies, taking advantage of the vast ...

    • RNase P: A promising molecular target for the development of new drugs 

      Tekos, A.; Stathopoulos, C.; Tsambaos, D.; Drainas, D. (2004)
      RNase P is an ubiquitous and essential endonuclease in tRNA biogenesis, which generates the mature 5′-termini of tRNAs. RNase P activities have been identified in all three kingdoms of life (Bacteria, Archaea, Eukarya). ...

    • Success Stories and Challenges Ahead in Hematopoietic Stem Cell Gene Therapy: Hemoglobinopathies as Disease Models 

      Yannaki E., Psatha N., Papadopoulou A., Athanasopoulos T., Gravanis A., Roubelakis M.G., Tsirigotis P., Anagnostopoulos A., Anagnou N.P., Vassilopoulos G. (2021)
      Gene therapy is a relatively novel field that amounts to around four decades of continuous growth with its good and bad moments. Currently, the field has entered the clinical arena with the ambition to fulfil its promises ...

    • Vascular endothelial growth factor (VEGF) in pleural effusions 

      Kiropoulos, T. S.; Daniil, Z.; Gourgoulianis, K. I.; Zakynthinos, E. (2007)
      Pleural effusion is a common clinical problem in everyday clinical practice. Vascular endothelial growth factor (VEGF) is a 34-45 kDa homodimeric glycoprotein, which is a potent mediator of angiogenesis and vascular ...